Successfully complete all VR Missions in Time Attack Mode. Time starts when you select your first mission. Time ends when you see the final mission's complete screen.
Menu Routing/General Info
Before the run, set up your menus so that you begin on Level 1 on each subset.
Before the run, select the top or bottom subset on each VR Mode. This way you go in ascending or descending order.
You want to start with Weapon Mode, so no suppressor is equipped for the Five-seveN.
Arguably, it is better to start from Nikita and go up to Five-seveN, as Nikita and Mine can lose a lot of time if failed in Weapon Mode.
Whether you do Sneaking Mode or Advanced Mode second is personal preference.
Saving ammo for IGT score is pointless, just make sure not to run out of ammo before taking out targets/enemies.
Two explosions and you are dead, be careful!
Explosive targets in Weapon Mode blow up into shards, the damage lasts longer than you think.
Try to always face down and be at the bottom of a goal, or else Snake needs to move.
Hold B during clear screens and intros to skip text.
It's faster to reset via the menu than to cause a Mission Fail.
Weapon Mode
Be careful with Nikita 03, as a fail loses a lot of time. Use the radar.
Don't pick up extra mines for IGT.
Mines are dangerous, two explosions and you die.
Be careful with Grenades that you don't run into the explosive shards from a target, they last longer than you think.
If you are unsure of your C4 position in C4 02, double up or detonate early so you do not need to double back.
R5 02's time limit is very strict, watch out!
Five-seveN 05 is particularly difficult.
Sneaking Mode
Single punch distractions are quite risky versus knockouts.
Assume bad luck for noises with Five-seveN to avoid getting caught.
No Weapon 05's noise luck is annoying, zigzag rather than running vertically to avoid guard luck.
07's laser manipulation is worth it, but if you mistime it (getting caught by lasers) you will lose time ultimately.
No Weapon 09's camera cycle can lose 15 seconds, so timing the movement properly is useful.
No Weapon 14 = bottom right, right, middle right conveyor belts
Five-seveN 14 = top left, bottom right, middle right conveyor belts
To deal with noise luck on No Weapon 15, crawl for a second or so when approaching the goal. If the second guard looks around from the noise, run around the top, as the top guard will intercept you.
Advanced Mode
Don't plan your kill strategies around Individual Level luck.
You can always kill a guard by punching them to death if other methods fail.
Five-seveN 03 and 05 are in the dark, watch the radar if you do not go for blind alert strategies.
Explosives in particular need extra care, as relying on guard luck is risky.
Nikita 05 can be done via the safe/intended route (bring the missile all the way around). This loses 10 seconds over the IL strategy. The IL strategy if failed will lose over 20 seconds.